Selank / TP-7
Synthetic Tuftsin-Derived Heptapeptide
CHEMICAL CLASS
Synthetic tuftsin-derived heptapeptide
PRIMARY RESEARCH DOMAIN
Neuroactive Peptides
Selank is a neuroactive research peptide within Alford Molecular Research's Research Compound Library. As a synthetic heptapeptide derived from the endogenous immunomodulatory peptide tuftsin, it is primarily investigated for its role in neuroactive signaling and stress-response pathways. This catalog entry provides technical molecular context for nonclinical institutional research only.
EVIDENCE CLASSIFICATION
Preliminary
PRIMARY RESEARCH AREAS
neuroactive peptide signaling; stress-response biology; cognitive signaling; anxiolytic mechanisms; neurotrophic pathways; neurotransmitter-related research
Compound
Selank
Aliases / Synonyms
TP-7; tuftsin analogue
Chemical Class
Synthetic tuftsin-derived heptapeptide
CAS Number
129954-34-3
PubChem CID
11765600
Molecular Formula
C33H57N11O9
Average Molecular Weight
approximately 751.88 g/mol
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Terminal State
Free N-terminus and free C-terminal carboxyl group unless otherwise specified by source material
Molecular Identity
Selank is a synthetic heptapeptide derived from the tuftsin sequence. It was originally developed as a neuroactive compound through the addition of a specific peptide fragment to the tuftsin structure. The resulting heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) preserves the core sequence of tuftsin while extending its molecular reach for neuroactive signaling research.
As a research tool, Selank is utilized in preclinical investigations focusing on neuroactive peptide signaling, stress-response biology, and cognitive signaling mechanisms. Its origin as a tuftsin-analogue provides a structural foundation for exploring peptide-based modulation in neurotrophic and neurotransmitter-related pathways. This molecule serves Alford Molecular Research's framework as a strictly nonclinical research compound, intended for laboratory investigation only.
Molecular Target / Mechanism
Selank is investigated as a neuroactive research peptide within Alford Molecular Research's Research Library. Its investigation focuses on its role in neuroactive signaling, anxiolytic mechanisms, and cognitive signaling pathways. Research models explore its interaction with neurotransmitter-related systems and its potential as a tool for studying stress-response biology. Current scientific inquiry remains focused on mechanistic characterization rather than therapeutic outcomes.
Intracellular Signaling
The intracellular signaling cascades relevant to Selank research involve neuroactive peptide pathways and neurotrophic signaling. Technical models study how the peptide interacts with stress-response biology at the cellular level, focusing on investigative molecular mechanisms. Experimental evidence aims to clarify the peptide's role in modulating signaling integrity within neuroactive research systems, maintaining a strictly technical and research-focused perspective.
Cellular & Tissue-Level Research
Selank has been investigated across a variety of preclinical models and cellular systems focused on neuroactive signaling. These investigations often employ stress-response paradigms and neural tissue assays to observe heptapeptide interactions within biological contexts. This data is cataloged for research-only purposes and does not imply clinical efficacy in human subjects.
Primary Research Areas
neuroactive peptide signaling
stress-response biology
cognitive signaling
anxiolytic mechanisms
neurotrophic pathways
neurotransmitter-related research
Translational Chain
The research record for Selank tracks a conceptual translational chain from identified molecular sequences to cellular signaling models. While early preclinical data exists, evidence remains restricted to these foundational tiers. Selank is categorized strictly as a research compound and is not positioned as an established therapeutic substance.
Evidence Assessment
Analytical & Quality-Control Considerations
Structural & Formulation Considerations
Evidence Summary
- Identity by Mass Spectrometry (MS)
- Purity by RP-HPLC or UPLC
- Quantitative net peptide content
- Exact sequence confirmation
- N-terminal and C-terminal state
- Counterion / salt state analysis
- Residual solvent detection
- Water content determination
- Degradation product profile
- Endotoxin and sterility testing (lot-specific)
Structural integrity of Selank as a heptapeptide analog is contingent upon precise synthesis and maintenance of the tuftsin-derived sequence. Research formulations focus on preserving molecular stability within neuroactive peptide signaling models and exploring peptide survival across diverse experimental environments, strictly for nonclinical laboratory evaluation.
Evidence: Preliminary
Selank is classified as possessing Preliminary evidence within the Research Compound Library. Current evidence remains limited to preliminary investigations; study design, route, formulation, population, and endpoint materially affect interpretation of data. Preclinical findings or early research models should not be generalized to established clinical benefit. Furthermore, route-specific findings observed in laboratory settings should not automatically be extrapolated to another delivery route or biological system.
Example Analytical Documentation
Alford Molecular Research has reviewed third-party analytical documentation for Selank research material including molecular-identity, quantitative-content, purity, and endotoxin testing. Analytical results are lot-specific and should not be generalized to other batches.
Stability & Handling — Scientific Context
Maintenance of secondary structure and avoidance of enzymatic degradation are primary considerations in the nonclinical investigation of neuroactive research peptides. Scientific context regarding handling focuses on peptide thermal stability, light sensitivity, and hygroscopic properties, ensuring data fidelity within stress-response and cognitive signaling research frameworks.
Research / Regulatory Context
Selank / TP-7 is classified as a synthetic Tuftsin-derived heptapeptide and is categorized as a neuroactive research peptide within Alford Molecular Research's framework. This compound is intended for scientific research and nonclinical investigation only. No regulatory approvals are implied, and the compound is not positioned for human use, diagnosis, or clinical applications.
Research Context Notice
IMPORTANT: The information provided is for scientific and research context only. Selank / TP-7 is strictly for laboratory evaluation and not for treatment, diagnosis, or human use. Alford Molecular Research, LLC does not provide medical recommendations or instructions for administration.